Reducing the risk of ovarian hyperstimulation syndrome in IVF

The world's first IVF baby, Louise Brown born in England in 1978, was conceived from a naturally developing follicle in her mother's ovary. However, as other groups around the world would quickly discover, the "natural cycle" was an inefficient and difficult procedure to replicate, and most turned to the 'stimulated' cycle to provide more eggs for fertilization and a greater chance of pregnancy. Since then, many combinations of fertility hormones have been tried to improve outcomes, but the stimulated cycle remains the cornerstone of today's IVF.