Researchers develop method to advance maturation of human pluripotent stem cell-derived heart cells

A Mount Sinai-led team has developed a reproducible and scalable method to advance maturation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs)—cells that support heart muscle contraction, generated in the lab from human stem cell lines—which researchers say will improve approaches for disease modeling, regenerative therapies, and drug testing. A study reporting this new protocol was published in the April 7 print edition of the journal Cell Stem Cell.